Vascular Extracellular Matrix Remodeling and Hypertension
نویسندگان
چکیده
منابع مشابه
Extracellular Matrix Remodeling in Hypertension
Increases in arterial blood pressure cause cumulative changes in tissue structure and function, resulting ultimately in end-organ damage. One of the pathological hallmarks of hypertensive tissue injury is an increase in tissue fibrosis, which leads to reductions in tissue compliance and function. Fibrosis (or sclerosis) occurs as result of marked changes in the amount and composition of the ext...
متن کاملExtracellular matrix remodeling: multiple paradigms in vascular disease.
Remodeling of the extracellular matrix is involved in the initiation and progression of a variety of diseases, including cancer1 and vascular pathology.2–6 However, our knowledge of the precise mechanisms that are involved in remodeling processes is still in its infancy. In this issue of Circulation Research, two studies, one by Bunton et al7 and one by Travis et al,8 provide important examples...
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Extracellular matrix (ECM) within the vascular network provides both a structural and regulatory role. The ECM is a dynamic composite of multiple proteins that form structures connecting cells within the network. Blood vessels are distended by blood pressure and, therefore, require ECM components with elasticity yet with enough tensile strength to resist rupture. The ECM is involved in conducti...
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The extracellular matrix provides a structural framework essential for the functional properties of vessel walls. The three dimensional organization of the extracellular matrix molecules - elastin, collagens, proteoglycans and structural glycoproteins - synthesized during fetal development - is optimal for these functions. In uninjured arteries and veins, some proteases are constitutively expre...
متن کاملIntegrins, vascular remodeling, and hypertension.
At the level of the resistance artery, hypertension also brings about a thickening of the vascular wall and inward encroachment on the lumen. This has been reported as being attributable to hypertrophy or hyperplasia of vascular smooth muscle cells (VSMCs), but studies have appeared suggesting that growth is not apparent in arteries at this level of the circulation.1 In addition, detailed struc...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2021
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2020.8110